Tag Archives: cannabis

Marijuana and Blood Pressure

Leave a reply

Does cannabis help with blood pressure? According to a cursory study, it might, but the results are a bit conflicting, with a limited amount of people actually showing different benefits. Some say that it may be a good agent to help with this. 

High blood pressure is an epidemic, and this is actually responsible for over half a million deaths within the US alone.  This of course, increases risk for stroke, heart disease, and death of course, with the prevalence increasing as you get older, and only about a quarter of adults have hypertension they’re controlling. This is serious, so it’s no wonder why people haven’t taken care of it, and also why they haven’t gotten the full ability to control this yet. 

Endocannabinoids and your Heart 

The endocannabinoid system is a big part of our body, with different neurotransmitters including 2-AG and anandamide as well in these, and they can actually be active receptors directly to the heart, helping with cardiac motions. It can also help with decreasing the damage to the tissue, along with arrhythmia, and in some cases they can halt the progression of other heart-related conditions including atherosclerosis. 

There is also some overwhelming evidence that this can actually help with vasodilation, reducing and normalizing the pressure of the blood. This can help to suppress cardiac contraction and hypertension, and also may help with normalizing the blood pressure further. 

Cannabis and Your blood pressure 

There was some animal research done clinically that establishes that THC does work to help with lowering the blood pressure of an animal. The findings did push for the use of medical cannabis to help with this, and in another study in 1979, it was found that those subjects that inhaled THC did have a small increase in their heart rate, and then the systolic and diastolic blood pressure dropped, and this of course, would last up to four hours, and sometimes was a bit more intense compared to other hypertension subjects that were studied. 

The enthusiasm did push for the potential of this, but this did get tempered when according to reports of the effects of medical cannabis treatments, it was found that the tolerance for this did help negative the hypotensive benefits of this, and other studies mentioned no particular evidence when it came to the development along with tolerance that was associated with the usage of THC continuously. 

According to a study that was published in Hypertension it was found that a lot of users who were middle-aged did have a small increase initially, but there was no increase in the diastolic blood pressure readings. Other studies said that they don’t have an initial increase, but instead, there was a soloing of the blood pressure along with the heart rate. 

This also has been further looked into. And, in a study in 2021, it wsa found that those who were prescribed the use of medical cannabis did have lower levels of diastolic and systolic blood pressure, with the main effects happening about three hours after the initial use of cannabis. 

While it seems like it may work, a big part of this is actually there are some other health concerns. Including the frequent usage of marijuana through smoking did result in higher chances of myocardial infarction along with stroke, and coronary artery disease, with a possible chance for cardiovascular disease prematurely. 

But, this type of thing doesn’t have the full risks associated with this, and there are other variables including the consumption of a

Phenibut and Weed 

Leave a reply

Phenibut is basically a drug that’s used to help with anxiety, and it’s been used like weed recreationally too in order to help with the euphoria that you have. There is actual research on weed and the body, but phenibut doesn’t have nearly as much. Some people have mentioned that mixing them does make you feel better, but there are some parts of the medical community that advise against the mixture of this, since there is nowhere near enough information. 

What Phenibut Is 

Phenibut is basically a drug that was created during the 1960s in the soviet union.  This was used in Russia as a type of medication. However, when it spread out to Hungary and Austria, this was considered a controlled substance, but in the rest of the world, this isn’t nearly as defined. 

The thing with phenibut, is that while there are supposed health benefits to this, there are no studies that say that you will get treated with this. In fact, the FDA doesn’t even approve of this as a supplement.  There isn’t much approval throughout the FDA, but you can buy this online as a type of supplement to help with nutrition. 

It’s considered a nootropic drug, which is basically a smart drug, or also known as a cognitive enhancer.  This means that it works to help with reducing the way the CNS works, and also works to help with reducing anxiety.

It’s since been used for a lot of different things, especially throughout eastern Europe as well, for different conditions including: 

  • Depression 
  • Stress and anxiety 
  • Insomnia 
  • PTSD 

This drug is known as a wonder drug, since it may make you feel good, but phenibut does not work that way. However, some people have mentioned they’re able to learn better, have better concentration and memory, and it boosts social skills, relieving the instances of social anxiety in the person.

It does create an antagonist to GABA, raising this, and it can help with reducing anxiety through making your GABA receptors work more. 

The benefits and Drawbacks 

There are some benefits and drawbacks that we can extrapolate from mixing these two together. The benefits include that they do work similarly on the ECS and the GABA receptors within this. Cannabis also does interact with these receptors. 

There is some preclinical research that did look at agonists of the CB receptors in the body, and drugs that improve GABA, so they do overlap each other. That does mean that it can possibly help. Some people on reddit have also said that they feel happier too, but of course that is reddit, and not a scientific body of knowledge.  

The risks mostly come from the fact that we don’t know much about it.

Some of the risks do include: 

  • Nausea 
  • Dizziness 
  • Headaches 
  • Fatigue 
  • Stomach issues 
  • Higher blood pressure 

This has been seen when people mix the two together. Another thing is that when you mix these in higher doses with something else, this can be potentially dangerous.  There is also the fact that, if you do recreationally combine these two together, it can impact how much you need to get similar effects and create a risk for creating a substance use disorder in someone.

Overall, if you have to use one or the other, you may want to talk to your doctor to see if it’s viable.  You should also be mindful of the potential risks that this can cause, and issues that do get exacerbated whenever you’re interested in using this substance too. 

All about Cannabis tinctures 

Leave a reply

Tinctures are one of the most common ways to take cannabis, especially for those who aren’t the biggest fans of vaping and smoking. They also offer benefits that do make them different from other types of concentrates. Some people may be curious if you can make tis, and it can actually be made with alcohol too! 

What are tinctures 

They’re basically extracts made via binding glycerin and alcohol, so it’s basically a liquid that’s infused with cannabis that you can add to drinks and foods. They’re great for people who want to take cannabis in a more discreet manner that’s straightforward, convenient, and something you can even make at home. Some people like to just use a couple drops, and they’re getting the best results out of this as well, especially with ho quick the can be to use. 

Alcohol and glycine 

The biggest thing that people use with their tinctures, is either glycerin or alcohol. This is something that a lot of people consider. However, you can actually bind it better with high-poor alcohol. That’s because the cannabinoids and THC are easy to bind with. Some people don’t like this one because it is not ideal for you to use, especially if you’re going to use this at work, or if you plan to use this a lot. 

Glycerin is something that’s odorless, colorless, and doesn’t have a flavor, and it’s able to be used in a variety of food products. It’s versatile, but it’s not as potent, so keep this in mind. The choice is something that’s based on the preference, and the ingredients. 

However, as of note, a couple of tinctures will not get you smashed. That’s because there’s nowhere near enough ethanol to help with this. 

Most of them have about 80 proof alcohol, which is something that is about the equivalent of using the vodka that you find at the store. 

It can make you a bit wavy if you drink it straight, but if you’re going to make a tincture with this, it will not get you messed up. 

How to make this. 

This is something that’s pretty simple, and has been used for thousands of years, and it’s something that’s considered superior in terms of how to make this. 

You have a lot of different options and strains, and different types of methods that help with this. You can let the tincture soak for a long time, and you can even make this in different ways. 

The most common is the golden dragon tincture, which makes it gold. 

Basically, to start, you’ve got to decarb the cannabis, which means that you heat it up to have the THCA become THC.  This usually takes about two hours for it to work, and you can then let this cool. Put this into a jar to seal. 

After that, you want to just throw this into the freezer, and take all of the ingredients, including the alcohol to make this work. This helps protect the trichomes and makes them brittle. 

Next, you want to agitate it, and then shake this around.  You want to shake this a few times for a few minutes, which will help get rid of the lipids, waxes, and the chlorophyll that was there wen frozen. 

Finally, you want to filter this. Take the mason jar out, get a coffee filter, then put te tincture mixture of alcohol with the cannabis through the filter so that there aren’t any impurities. Use a pipette to load this, and then there you go, you’ve got perfect tinctures availible right at home! 

Can you mix  Cannabis and Coffee 

Leave a reply

Right now, we don’t’ see much of a connection between cannabis and coffee, but there is some suggestions which state that putting these two together can make a unique experience, different from what you get when you use them in an individual sense. 

You can take them at the same time, such as smoking as well while consuming coffee, but there is no solid evidence for this. However, mixing the pills that contain caffeine may be much different from mixing cannabis with coffee and teas directly, and it’s important to look at some of the other compounds. 

L-theanine may be good for those who are jittery to caffeine, and it’s found in tea, and that can combat the effects that happen with coffee. It also may help with reducing the memory and cognitive issues commonly associated with THC in most cases. 

Coffee as well also contains trigonelline which is basically a neuroprotective and anti-migraine and anti-tumor compound, and it may be good to mix with cannabis, as it can enhance this. 

What caffeine is 

Caffeine is a stimulant that’s psychoactive, and it’s in a lot of drinks.  It is also delivered in supplements, chocolate, and even some other plants. This stimulates your CNS, helping people feel more awake and alert, simply doing so through the binding of the receptors, preventing adenosine uptake, which is basically the chemical that makes you sleepy, and something that does naturally build throughout the day. 

Caffeine also does increase the levels of adrenaline in the body, boosting both dopamine and norepinephrine levels as well, helping you feel happy, focused, and alert. It does hit the system quite fast, about 20 minutes or so. It can help with memory concentration, reducing neurological disorders and risk for Alzheimer’s as well. It’s also naturally neuroprotective, and it is also from the chlorogenic acid that’s found in this, a natural antioxidant as well. 

Mixing cannabis with Caffeine 

Right now, there isn’t much research on whether or not that’s good or bad. Some evidence says that if you mix this together, it can affect the adenosine as well, since the cannabis is working directly with the endocannabinoid system as well. 

It also may improve how cognitively impaired the cannabis may make you feel, so you can get the benefits without feeling as high as well. The CBD inside cannabis may also be good as well, and it can impact the different depressive elements as well that come from some of the strains that are there. It also may not increase how much stimulant you’re getting either. 

There was a study that was done in 2011 that looked at how monkeys behave when they have cannabis, usually a small one milligram dose of this. It wsa found that though the monkeys didn’t have a ton of limiting to marijuana, they were consuming a bit less cannabis as well. 

There was another study that was done in 2017 that also did discover the caffeine along with the cannabis that wsa in there, increasing the levels of dopamine in there, and this is all through different mechanism. The authors decided, when they were taken together, caffeine and cannabis could create happiness and euphoria. 

It can also help with the shakiness that you experience as well. Some people noticed that the locomotion sensitivity that they had when they normally drank coffee was mitigated through the use of the CBD in cannabis. 

So yes, it can be something to consider, and it’s something that may be good to use, just note that there aren’t too many studies that validate these effects yet.