When you use Zoloft, you do possibly create some bad effects with certain drugs. For weed, it can enhance these bad effects, and also reduce how impactful Zoloft can be for you.
What’s Zoloft?
This is an SSRI that’s available to help with depression symptoms. It can also help with panic disorders and conditions too. It does interact with other drugs, including other antidepressants, and marijuana can conflict with many antidepressants, which is why you should always talk to your doctor before you decide to combine these drugs together.
Zoloft usually helps with managing depression disorders, but also other problems.
Some of them include:
- Major depressive disorder
- Premenstrual dysphoric disorder
- PTSD
- Social anxiety
- Panic Disorders
- OCD
This helps to balance out the serotonin within the brain. Serotonin, for those who don’t know, is basically that chemical which helps with controlling the mood, rewarding different responses, and other sorts of functions too. When these get too low, you can start to feel bad effects as a result of it, such as maybe social anxiety or panic attacks.
Benefits and Drawbacks
The most important thing to understand is mixing cannabis with any prescription medication does create adverse reactions in a lot of people. Some people may not experience a ton of bad effects. You should however, always talk to your doctor before you use this.

It can help those who struggle with mental health concerns. If you already have low levels of serotonin, you may want to possibly use this. However, there is also a condition called serotonin syndrome, which means that your serotonin levels are at too high of a level.
The symptoms include:
- A 101 degree or higher fever
- High blood pressure
- A rapid heart rate
- Loss of coordination in the muscles
- Weakness in a general sense
- Panic attacks and insomnia
- Confusion and agitation
If you have these symptoms, you should always seek out medical help immediately. You definitely want to also get help for this if you are experiencing other potentially fatal other conditions that happen with this.
It’s also important to understand that mixing these together can make OCD and panic attacks worse for you. The side effects may also get worse too. Zoloft and cannabis both can create drowsiness or dry mouth, and they may become much more pronounced the more of bot you take.

You may also experience the following that gets more intense too:
- Appetite loss
- Nervousness
- Dizziness
- Insomnia, and other kinds of sleep issues
These can sometimes be mild symptoms, or major issues.
If you do need to use both of these, you should always make sure that you do this under the guise of a doctor.
The side effects sme be mild, or even moderate, and if you decide that you do need both, you should make sure that you follow the instructions.
If you’re going to combine them, you want to make sure that you do try to have the smallest amount that you can. You should talk to the doctor to get yourself onto the right dosage that’s there.
If your doctor says to discontinue, you can do so, however, this is one of these SSRIS that’s hard to quit once you start to take it, and it can make the symptoms worse when you quit, so keep that in mind if you do decide to quit this type of item.
If you’re not sure about whether or not you should use Zoloft with cannabis, always discuss it with your doctor.